Protein Modification Reagents
Medchemexpress LLC Cholesterol-PEG-biotin | 2000 (average) | (C2H4O)nC40H66N4O4S | 50 MG
Cholesterol-PEG-Biotin (MW 2000) is a PEGylated lipid conjugate combining a cholesterol anchor with a biotin tag via an approximate 2,000 Da PEG spacer. It is designed to incorporate into lipid bilayers or liposomes and present biotin for high-affinity binding to avidin or streptavidin, enabling surface immobilization, targeted capture, and bioconjugation in biochemical and nanotechnology applications. Supplied as a powder with low-temperature storage recommendations.
- Provides a biotin handle for strong avidin/streptavidin binding.
- Anchors to lipid membranes via a cholesterol moiety.
- Peg spacer increases aqueous solubility and reduces steric hindrance.
- Enables liposome functionalization and surface immobilization.
- Supplied as a powder with recommended low-temperature storage.
Medchemexpress LLC 4-Arm PEG-SCM MW 10 100mg
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
Medchemexpress LLC 3,6,9,12,15,18-hexaoxanonadecanoic acid | 16142-03-3 | 99.9% | 310.34 | C13H26O8 | 250 MG
m-PEG5-CH2COOH is a methyl-terminated PEG5 linker bearing a terminal carboxylic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC linker synthesis as well as general bioconjugation and medicinal chemistry research.
- High purity (99.9%).
- Methyl-terminated PEG5 chain with a terminal carboxylic acid functional group.
- Suitable for ADC and PROTAC linker synthesis and general bioconjugation.
- Soluble in DMSO at 200 mg/mL; sonication recommended.
- Stable when stored sealed and protected from moisture; in solution store at -80°C (6 months) or -20°C (1 month).
- Supplied in research-scale packaging suitable for synthetic workflows.
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | 96.8% | 755.73 | C34H41N7O13 | 5 MG
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide reactive group, a two-unit polyethylene glycol spacer, and a protease-sensitive Val-Cit-PABA peptide spacer that enables payload release in target cells.
- cleavable linker for ADC synthesis
- contains maleimide (Mal) reactive group
- two-unit PEG spacer (PEG2) provides solubility and flexibility
- val-cit-paba sequence is protease sensitive for intracellular release
- para-nitrophenyl (PNP) activating group for conjugation chemistry
- solid, white to off-white appearance; high purity
- available in multiple sizes and requires protection from light and storage under inert gas
Medchemexpress LLC Biotin-PEG4-NHS ester | 459426-22-3 | MFCD08458915 | 99.6% | C25H40N4O10S | 500 MG
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker. It is designed for use in the synthesis of PROTACs, compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Designed for use in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand binds to the target protein
Medchemexpress LLC DSPE-PEG-DBCO sodium | 2052955-83-4 | 95.0% | 5000 (average) | 1 MG
DSPE-PEG-DBCO sodium (MW 5000) is a PEGylated phospholipid that combines a DSPE lipid anchor with a dibenzocyclooctyne (DBCO) reactive handle, designed for incorporation into lipid formulations and for strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation in drug delivery research.
- Pegylated lipid with DBCO functionality for copper-free click chemistry.
- Sodium salt form supplied as a white to yellow solid.
- Average molecular weight approximately 5000 daltons.
- Purity approximately 95% by supplier analysis.
- Enables liposome and nanoparticle surface functionalization.
- Store at -20°C and protect from light; follow solvent storage guidance for long-term stability.
Medchemexpress LLC Ma-PEG4-VC-PAB-DMEA-duocarmycin DM | 99.8% | 1381.96 g/mol | C68H89ClN12O17 | 5 MG
MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate intended for use in the construction of antibody-drug conjugates (ADCs). The cytotoxic payload is a DNA minor-groove alkylator; the product is supplied for research use only and includes analytical documentation (COA, HNMR, RP-HPLC).
- High purity suitable for research applications.
- Contains a duocarmycin DM DNA minor-groove alkylator payload.
- Solid, white to off-white appearance for easy handling.
- Available in small research sizes for early-stage studies.
- Analytical documentation and safety data available.
- Recommended to store protected from light and under inert atmosphere.
Medchemexpress LLC Boc-NH-PEG4-CH2COOH | 876345-13-0 | MFCD30528568 | >97.0% | 351.39 g/mol | C15H29NO8 | 250 MG
Boc-NH-PEG4-CH2COOH is a Boc-protected PEG4 linker with a terminal carboxylic acid offered for research use. It is used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis. The product is supplied in multiple package sizes and is provided with analytical purity appropriate for research applications.
- Boc-protected PEG4 linker with terminal carboxylic acid.
- Suitable for ADC and PROTAC linker applications.
- High reported purity for research use.
- Available in small-scale and bulk package sizes.
- Molecular weight 351.39 g/mol; formula C15H29NO8.
Medchemexpress LLC Nhpi-PEG2-C2-NHS ester | 2101206-31-7 | 98.2% | 420.37 g·mol⁻¹ | C19H20N2O9 | 100 MG
NHPI-PEG2-C2-NHS ester is a noncleavable 2-unit polyethylene glycol (PEG) linker bearing an NHPI leaving group and an NHS ester, designed for stable bioconjugation in antibody-drug conjugate (ADC) synthesis.
- Noncleavable 2-unit PEG linker suitable for ADCs and bioconjugation.
- NHS ester functional group enables efficient coupling to primary amines.
- Reported purity 98.23% and molecular weight 420.37 g·mol⁻¹.
- Molecular formula C19H20N2O9; supplied as a solid in 100 MG packages.
eMolecules Propargyl-PEG6-amine | Combi-Blocks, Inc. | 1198080-04-4 | MFCD29042376 | 319.398 | C15H29NO6 | 95.000 | NCCOCCOCCOCCOCCOCCOCC#C | 5g | 603148135
Propargyl-PEG6-amine | Combi-Blocks, Inc. | 1198080-04-4 | MFCD29042376 | 319.398 | C15H29NO6 | 95.000 | NCCOCCOCCOCCOCCOCCOCC#C | 5g | 603148135
Medchemexpress LLC DSPE-PEG-FITC | 95.0% | 600 (average) | 50 MG
DSPE-PEG-FITC (MW 600) is a fluorescein-labeled PEGylated lipid used as a fluorescent probe for incorporation into liposomes, lipid nanoparticles, and membrane-labeling applications. It is supplied as a light yellow to yellow solid, has an average molecular weight of ~600, and is intended for laboratory research use.
- Provides fluorescent labeling via FITC for visualization and tracking.
- PEGylated lipid anchor enables stable incorporation into membranes and nanoparticles.
- Average molecular weight approximately 600 for predictable behavior in formulations.
- Light yellow to yellow solid suitable for standard laboratory handling.
- Recommended storage at 4°C with protection from light; in solvent: -80°C up to 6 months or -20°C up to 1 month.
- Purity tested at 95.0% per manufacturer certificate of analysis.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 50 MG
A cleavable 11-unit polyethylene glycol (PEG) linker containing an azide functional group for click chemistry and bioconjugation applications. Intended for research use only.
- Cleavable 11-unit PEG linker suitable for antibody-drug conjugates and bioconjugation
- Contains an azide (N3) functional group for CuAAC and SPAAC click reactions
- Available in multiple package sizes, including 50 MG
- Appearance: oil, colorless to light yellow
- Molecular weight 1147.31; molecular formula C48H94N10O21
- Store sealed away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month)
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | MFCD24539465 | 98.6% | 354.31 | C15H18N2O8 | 5 G
Mal-PEG2-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker that contains a maleimide thiol-reactive group, a two-unit polyethylene glycol (PEG2) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied as a viscous, colorless to off-white liquid and is used for thiol-to-amine bioconjugation in ADC construction and other protein labeling applications.
- Non-cleavable maleimide-NHS bifunctional linker.
- 2-unit PEG spacer improves solubility and reduces aggregation.
- Thiol-reactive maleimide enables cysteine conjugation.
- NHS ester enables coupling to primary amines.
- High purity (≈98.6%) suitable for research applications.
- Available in multiple pack sizes, including 5 G.
- Recommended storage: -20°C (pure), -80°C (in solvent) per supplier storage instructions.
eMolecules Broadpharm / DBCO-NHCO-PEG4-acid / 25mg / 353441826 / BP-23760 / / 2110448-99-0 / MFCD31380393 / 552.624 / C30H36N2O8
Broadpharm / DBCO-NHCO-PEG4-acid / 25mg / 353441826 / BP-23760 / / 2110448-99-0 / MFCD31380393 / 552.624 / C30H36N2O8
Medchemexpress LLC Dbco-peg4-tamra | 1895849-41-8 | 96.2% | 936.06 | C54H57N5O10 | 10 MG
DBCO-PEG4-TAMRA is a PEG-linked TAMRA fluorescent dye functionalized with a dibenzocyclooctyne (DBCO) group to enable copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) for bioconjugation. It is supplied as a solid with high purity for labeling azide-containing biomolecules in imaging and analytical workflows.
- Enables copper-free click chemistry conjugation.
- PEG4 spacer improves solubility and reduces steric hindrance.
- TAMRA fluorophore for red fluorescence detection.
- Provided as a solid, light brown to brown in color.
- Storage: store at -20°C, protect from light, under nitrogen.
- High purity (≈96.2%) suitable for research applications.